ARI Publication 40 – 2013 Version

Ito H etal, Rndingsofbrain 99mTc-EGJSPECTin high-li.Jnctioningautism-3-dimensionalstereotadicROItemplate
analysisofbrain SPECT. J MedInvest. 2005Feb;52(1-2):49-56. (15d7i/clren with autism, 5 d7ilclren with
epilepsy)
Gupta SK, Ratnam BV. Cerebralperfusion abnormalities in children with autism and mental retardation:
a segmental quantitative SPECTstudy. Indian Pediatr. 2009 Feb;46(2):161-4. (10 children with
autism, 5 typical children)
Sasaki M, et al Brain perfusion SPECT and EEG findings in children with autism spectrum disorders
and medically intractable epilepsy. Brain Dev. 2010 Oct;32(9):776-82. Epub 2010 Jul 1. (15
children with autism)
Yang WH et al, Regional cerebral blood flow in children with autism spectrum disorders: a quantitative
9 9mTc-ECD brain SPECTstudy with statisticalparametric mapping evaluation. Chin Med J
(Englj. 2011 May;124(9):1362-6. (23 children with autism, 8 controls)
Duchesnay E, etal, Feature selection and classification ofimbalanced datasets: application to PET
images ofchildren with autistic spectrum disorders. Neuroimage. 2011 Aug 1;57(3):1003-14. £pub
2011 May 10. (45 children with autism, 13 control children)

Research on effect of HBOT on brain hypoperfusion
HBOT has been reported to at least temporarily improve brain hypoperfusion in two open-label
studies of other conditions (veterans with post-concussion syndrome and patients with various
chronic brain injuries).

Harch P, et al A Phase I Study ofLow Pressure Hyperbaric Oxygen Therapy for Blast-Induced Post
Concussion Syndrome and Post Traumatic Stress Disorder.
J Neurotrauma 2012, 29(1):168-185.
Golden ZL et al, A: Improvement in cerebral metabolism in chronic brain injury after hyperbaric oxygen
therapy. Int
J Neurosci 2002, 112(2):11~131.

Formal research studies of the possible effect of HBOT on brain hypoperfusion in individuals with
autism are needed to determine if it is helpful. Investigation of the effect on inflammation, such as
elevations of CRP, would also be very useful.

Agape is proud to have
been involved in this study and
mentioned on page 16.

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